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Version: 16.11d (Release date: 2016-11-28)
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Tesetaxel (Code C37451)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Tesetaxel

Definition: A semi-synthetic, orally bioavailable taxane derivative with potential antineoplastic and antiangiogenic properties. Tesetaxel binds to and stabilizes tubulin, promoting microtubule assembly and thereby preventing microtubule depolymerization. This may lead to cell cycle arrest and an inhibition of cell proliferation. This agent may also inhibit pro-angiogenic factors such as vascular endothelial growth factor (VEGF). As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors.

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. It is a type of taxane derivative.

Display Name: Tesetaxel

Label: Tesetaxel

NCI Thesaurus Code: C37451 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1872681  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
DJ-927
Tesetaxel
TESETAXEL

External Source Codes: 
CAS Registry Number 333754-36-2 (see NLM ChemIDplus info)
FDA UNII Code UG97LO5M8Y
PDQ Closed Trial Search ID 666079
PDQ Open Trial Search ID 666079 (check for NCI PDQ open clinical trial info)
UMLS CUI C1872681

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C46H60FN3O13
code C37451
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name DJ-927
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C37451

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