|Tesetaxel (Code C37451)|
|Terms & Properties|
Preferred Name: Tesetaxel
Definition: A semi-synthetic, orally bioavailable taxane derivative with potential antineoplastic and antiangiogenic properties. Tesetaxel binds to and stabilizes tubulin, promoting microtubule assembly and thereby preventing microtubule depolymerization. This may lead to cell cycle arrest and an inhibition of cell proliferation. This agent may also inhibit pro-angiogenic factors such as vascular endothelial growth factor (VEGF). As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors.
NCI-GLOSS Definition: A substance being studied in the treatment of cancer. It is a type of taxane derivative.
Display Name: Tesetaxel
NCI Metathesaurus Link: C1872681 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
External Source Codes:
|CAS Registry Number||333754-36-2 (see NLM ChemIDplus info)|
|FDA UNII Code||UG97LO5M8Y|
|PDQ Closed Trial Search ID||666079|
|PDQ Open Trial Search ID||666079 (check for NCI PDQ open clinical trial info)|
|Name||Value (qualifiers indented underneath)|
Additional Concept Data:
|Defined Fully by Roles: No|