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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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ABT-510 (Code C37447)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: ABT-510

Definition: A synthetic peptide that mimics the anti-angiogenic activity of the endogenous protein thrombospondin-1 (TSP-1). ABT-510 inhibits the actions of several pro-angiogenic growth factors important to tumor neovascularization; these pro-angiogenic growth factors include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF)), hepatocyte growth factor (HGF), and interleukin 8 (IL-8). (NCI04)

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. It is a type of angiogenesis inhibitor.

Display Name: ABT-510

Label: ABT-510

NCI Thesaurus Code: C37447 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1704426  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ABT-510

External Source Codes: 
PDQ Closed Trial Search ID 350157
PDQ Open Trial Search ID 350157 (check for NCI PDQ open clinical trial info)
UMLS CUI C1704426

Other Properties:
     Name Value (qualifiers indented underneath)
code C37447
Contributing_Source CTRP
Legacy_Concept_Name ABT-510
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C37447

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