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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Cimetidine (Code C374)

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Terms & Properties

Preferred Name: Cimetidine

Definition: A histamine H(2)-receptor antagonist. Enhancing anti-tumor cell-mediated responses, cimetidine blocks histamine's ability to stimulate suppressor T lymphocyte activity and to inhibit natural killer (NK) cell activity and interleukin-2 production. Cimetidine also may inhibit tumor growth by suppressing histamine's growth-factor activity and blocking histamine-induced stimulation of vascular endothelial growth factor (VEGF), a pro-angiogenic growth factor. (NCI04)

NCI-GLOSS Definition: A drug usually used to treat stomach ulcers and heartburn. It is also commonly used in a regimen to prevent allergic reactions.

Display Name: Cimetidine

Label: Cimetidine

NCI Thesaurus Code: C374 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0008783  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Guanidine, N''-Cyano-N-Methyl-N'-(2-(((5-Methyl-1H-Imidazol-4-yl)Methyl)Thio)Ethyl)-

External Source Codes: 
CAS Registry Number 51481-61-9 (see NLM ChemIDplus info)
FDA UNII Code 80061L1WGD
ChEBI ID CHEBI:3699 (see ChEBI info)
NSC Code 335308 (see NCI DTP info)
PDQ Closed Trial Search ID 39185
PDQ Open Trial Search ID 39185 (check for NCI PDQ open clinical trial info)
UMLS CUI C0008783

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Gastrointestinal conditions; allergic reaction prevention; immune modulation
Chemical_Formula C10H16N6S
code C374
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Cimetidine
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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