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Version: 17.06d (Release date: 2017-06-26)
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Chlorpromazine (Code C367)

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Terms & Properties

Preferred Name: Chlorpromazine

Definition: A phenothiazine and traditional antipsychotic agent with anti-emetic activity. Chlorpromazine exerts its antipsychotic effect by blocking postsynaptic dopamine receptors in cortical and limbic areas of the brain, thereby preventing the excess of dopamine in the brain. This leads to a reduction in psychotic symptoms, such as hallucinations and delusions. Chlorpromazine appears to exert its anti-emetic activity by blocking the dopamine receptors in the chemical trigger zone (CTZ) in the brain, thereby relieving nausea and vomiting.

Label: Chlorpromazine

NCI Thesaurus Code: C367 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0008286  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Chloro-10-(3-(dimethylamino)propyl)phenothiazine
Chlor-PZ
CHLORPROMAZINE
Chlorpromazine
Thorazine

External Source Codes: 
CAS Registry Number 50-53-3 (see NLM ChemIDplus info)
FDA UNII Code U42B7VYA4P
ChEBI ID CHEBI:3647 (see ChEBI info)
NSC Code 167745 (see NCI DTP info)
PDQ Closed Trial Search ID 39752
PDQ Open Trial Search ID 39752 (check for NCI PDQ open clinical trial info)
UMLS CUI C0008286

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C17H19ClN2S
code C367
Contributing_Source FDA
Legacy_Concept_Name Chlorpromazine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C367

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