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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Chlorhexidine (Code C364)

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Terms & Properties

Preferred Name: Chlorhexidine

Definition: A biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they are more sensitive to this agent.

Display Name: Chlorhexidine

Label: Chlorhexidine

NCI Thesaurus Code: C364 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0008196  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
CAS Registry Number 55-56-1 (see NLM ChemIDplus info)
ChEBI ID CHEBI:3614 (see ChEBI info)
PDQ Closed Trial Search ID 41544
PDQ Open Trial Search ID 41544 (check for NCI PDQ open clinical trial info)
UMLS CUI C0008196

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C22H30Cl2N10
code C364
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Chlorhexidine
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  


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