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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Ceramide (Code C359)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Ceramide

Definition: One of a number of a class of sphingolipids, N-acyl derivatives with long chains. Ceramide is the core molecule for the synthesis of sphingomyelin, an essential lipid for myelination and neurotransmission; it may function as a second messenger to stimulate differentiation, inhibit proliferation, and induce apoptosis. (NCI04)

NCI-GLOSS Definition: A type of lipid (fat) found in the membranes of cells and the covers of nerves. Some ceramides are important in signal transduction (the process by which a cell responds to substances in its environment) and may cause some types of cells to die. Ceramides are being studied in the treatment of cancer.

Display Name: Ceramide

Label: Ceramide

NCI Thesaurus Code: C359 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0007745  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ceramide
ceramide
Ceramide (lipids)
N-Acyl Sphingosine

External Source Codes: 
CAS Registry Number 104404-17-3 (see NLM ChemIDplus info)
ChEBI ID CHEBI:17761 (see ChEBI info)
NSC Code 720500 (see NCI DTP info)
PDQ Closed Trial Search ID 38167
PDQ Open Trial Search ID 38167 (check for NCI PDQ open clinical trial info)
UMLS CUI C0007745

Other Properties:
     Name Value (qualifiers indented underneath)
code C359
Contributing_Source CTRP
Legacy_Concept_Name Ceramide
Semantic_Type Biologically Active Substance
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C359

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