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Version: 17.06d (Release date: 2017-06-26)
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Cephalexin (Code C356)

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Terms & Properties

Preferred Name: Cephalexin

Definition: A beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephalexin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linking of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to second and third generation cephalosporins, cephalexin is more active against gram-positive and less active against gram-negative organisms.

NCI-GLOSS Definition: An antibiotic drug that belongs to the family of drugs called cephalosporins.

Display Name: Cephalexin

Label: Cephalexin

NCI Thesaurus Code: C356 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0007716  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Cephalexin
CEPHALEXIN
cephalexin
Keflex

External Source Codes: 
CAS Registry Number 23325-78-2 (see NLM ChemIDplus info)
FDA UNII Code OBN7UDS42Y
ChEBI ID CHEBI:3535 (see ChEBI info)
PDQ Closed Trial Search ID 43417
PDQ Open Trial Search ID 43417 (check for NCI PDQ open clinical trial info)
UMLS CUI C0007716

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C16H17N3O4S.H2O
code C356
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Cephalexin
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C356

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