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Version: 17.06d (Release date: 2017-06-26)
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Ceftazidime Sodium (Code C355)

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Terms & Properties

Preferred Name: Ceftazidime Sodium

Definition: The sodium salt of ceftazidime, a third-generation cephalosporin antibiotic with bactericidal activity. Ceftazidime binds to and inactivates penicillin-binding proteins (PBPs), enzymes located on the inner membrane of the bacterial cell wall, resulting in the weakening of the bacterial cell wall and cell lysis. Compared to the second and first generation cephalosporins, ceftazidime is more active against gram-negative bacteria and less active against gram-positive bacteria. Ceftazidine also crosses the blood-brain barrier and reaches therapeutic concentrations in the central nervous system (CNS). PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity.

Label: Ceftazidime Sodium

NCI Thesaurus Code: C355 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0700860  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CEFTAZIDIME SODIUM
Ceftazidime Sodium
Tazicef

External Source Codes: 
CAS Registry Number 78439-06-2 (see NLM ChemIDplus info)
FDA UNII Code CMC30V039K
PDQ Closed Trial Search ID 39179
PDQ Open Trial Search ID 39179 (check for NCI PDQ open clinical trial info)
UMLS CUI C0700860

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C22H21N6O7S2.Na
code C355
Contributing_Source FDA
Legacy_Concept_Name Ceftazidime
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C355

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