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Version: 17.06d (Release date: 2017-06-26)
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Cefotaxime (Code C354)

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Terms & Properties

Preferred Name: Cefotaxime

Definition: A third generation semisynthetic cephalosporin antibiotic with bactericidal activity. Cefotaxime inhibits mucopeptide synthesis by binding to and inactivating penicillin binding proteins thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of bacterial cell walls. This results in a reduction of cell wall stability and causes cell lysis.

Label: Cefotaxime

NCI Thesaurus Code: C354 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0007554  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
CAS Registry Number 63527-52-6 (see NLM ChemIDplus info)
ChEBI ID CHEBI:204928 (see ChEBI info)
PDQ Closed Trial Search ID 39177
PDQ Open Trial Search ID 39177 (check for NCI PDQ open clinical trial info)
UMLS CUI C0007554

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C16H17N5O7S2
code C354
Contributing_Source FDA
Legacy_Concept_Name Cefotaxime
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  


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