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Version: 17.06d (Release date: 2017-06-26)
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Carubicin (Code C352)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Carubicin

Definition: An anthracycline antineoplastic antibiotic isolated from the bacterium Actinomadura carminata. Carubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.

Label: Carubicin

NCI Thesaurus Code: C352 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0007308  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(2S,3S)-3-acetyl-1,2,3,4,6,11-hexahydro-3,5,10,12-tetrahydroxy-6,11-dioxo-1-naphthacenyl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside
(8S-cis)-acetyl-10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-5,12-naphthacenedione
4-O-demethyldaunorubicin
5,12-naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-1,6,8,11-tetra-hydroxy-(8S-cis)-(8CI 9CI)
5,12-naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-1,6,8,11-tetra-hydroxy-,(8S-cis)-(8CI)-(9CI)
5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3, 6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy]-7,8,9, 10-tetrahydro-1,6,8,11-tetra-hydroxy- (8S-cis)- (8CI 9CI)
Carminomycin
CARMINOMYCIN
Carminomycin I
Carubicin
CARUBICIN
CMM
Demethyldaunomycin
Karminomitsin
Karminomycin

External Source Codes: 
CAS Registry Number 50935-04-1 (see NLM ChemIDplus info)
FDA UNII Code E7437K3983
NSC Code 180024 (see NCI DTP info)
PDQ Closed Trial Search ID 39175
PDQ Open Trial Search ID 39175 (check for NCI PDQ open clinical trial info)
UMLS CUI C0007308

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C26H27NO10
code C352
Contributing_Source FDA
Legacy_Concept_Name Carubicin
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C352

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