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Version: 17.06d (Release date: 2017-06-26)
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Carmustine (Code C349)

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Terms & Properties

Preferred Name: Carmustine

Definition: An antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. (NCI04)

NCI-GLOSS Definition: An anticancer drug that belongs to the family of drugs called alkylating agents.

Display Name: Carmustine

Label: Carmustine

NCI Thesaurus Code: C349 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0007257  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1,3-Bis(2-chloroethyl)-1-nitrosourea
1,3-Bis(beta-chloroethyl)-1-nitrosourea
BCNU
Becenum
Becenun
BiCNU
Bis(chloroethyl) Nitrosourea
Bis-Chloronitrosourea
Carmubris
Carmustin
Carmustine
carmustine
CARMUSTINE
Carmustinum
FDA 0345
Gliadel
N,N'-bis(2-chloroethyl)-N-nitrosourea
N,N'-Bis(2-chloroethyl)-N-nitrosourea
Nitrourean
Nitrumon
SK 27702
SRI 1720
WR-139021

External Source Codes: 
CAS Registry Number 154-93-8 (see NLM ChemIDplus info)
FDA UNII Code U68WG3173Y
ChEBI ID CHEBI:3423 (see ChEBI info)
NSC Code 409962 (see NCI DTP info)
PDQ Closed Trial Search ID 43027
PDQ Open Trial Search ID 43027 (check for NCI PDQ open clinical trial info)
UMLS CUI C0007257

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Brain tumors; colon cancer; lung cancer; lymphomas; Hodgkins and Non-Hodgkins; melanoma; multiple myeloma; mycosis fungoides
Chemical_Formula C5H9Cl2N3O2
code C349
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Carmustine
Semantic_Type Hazardous or Poisonous Substance
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C349

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