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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Glucarpidase (Code C346)

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Terms & Properties

Preferred Name: Glucarpidase

Definition: A zinc-dependent enzyme isolated from a strain of the bacterium Pseudomonas. Because glucarpidase rapidly hydrolyzes methotrexate into inactive metabolites, it may be useful as a rescue agent for methotrexate-induced nephrotoxicity. In antibody-directed enzyme prodrug therapy (ADEPT), this agent is conjugated with an antibody that binds to a specific tumor cell type, allowing for glucarpidase-catalyzed activation of a co-administered prodrug at the site of the tumor.

NCI-GLOSS Definition: A bacterial enzyme that breaks down proteins and other substances, including methotrexate. It is being studied in the treatment of toxic effects caused by methotrexate. It may also help activate certain drugs to kill cancer cells. It is a type of chemoprotective agent and a type of prodrug activator.

Display Name: Glucarpidase

Label: Glucarpidase

NCI Thesaurus Code: C346 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0007072  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Carboxypeptidase G2

External Source Codes: 
CAS Registry Number 9074-87-7 (see NLM ChemIDplus info)
NSC Code 641273 (see NCI DTP info)
NSC Code 732443 (see NCI DTP info)
PDQ Closed Trial Search ID 41665
PDQ Open Trial Search ID 41665 (check for NCI PDQ open clinical trial info)
UMLS CUI C0007072

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C20H20O4
code C346
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Carboxypeptidase-G2
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  


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