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Version: 16.11d (Release date: 2016-11-28)
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Captopril (Code C340)

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Terms & Properties

Preferred Name: Captopril

Definition: A sulfhydryl-containing analog of proline with antihypertensive activity and potential antineoplastic activity. Captopril competitively inhibits angiotensin converting enzyme (ACE), thereby decreasing levels of angiotensin II, increasing plasma renin activity, and decreasing aldosterone secretion. This agent may also inhibit tumor angiogenesis by inhibiting endothelial cell matrix metalloproteinases (MMPs) and endothelial cell migration. Captopril may also exhibit antineoplastic activity independent of effects on tumor angiogenesis. (NCI04)

NCI-GLOSS Definition: A drug used to treat high blood pressure that is also being studied in the prevention of side effects caused by radiation therapy used in the treatment of cancer. It belongs to the family of drugs called ACE inhibitors.

Label: Captopril

NCI Thesaurus Code: C340 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0006938  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(S)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline
Capoten
CAPTOPRIL
Captopril
captopril

External Source Codes: 
CAS Registry Number 62571-86-2 (see NLM ChemIDplus info)
FDA UNII Code 9G64RSX1XD
ChEBI ID CHEBI:3380 (see ChEBI info)
NSC Code 719847 (see NCI DTP info)
PDQ Closed Trial Search ID 37824
PDQ Open Trial Search ID 37824 (check for NCI PDQ open clinical trial info)
UMLS CUI C0006938

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Hypertension; Heart failure; Left ventricular dysfunction; Diabetic nephropathy
Chemical_Formula C9H15NO3S
code C340
Contributing_Source FDA
Legacy_Concept_Name Captopril
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C340

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