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Version: 17.12d (Release date: 2017-12-26)
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Peginterferon Alfa-2a (Code C33987)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Peginterferon Alfa-2a

Definition: A covalent conjugate of recombinant interferon alfa, subtype 2a, and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent. The biological activity of this agent is derived from its interferon alpha-2a protein moiety. Interferons alfa bind to specific cell-surface receptors, leading to the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer and immune-modulating effects. The PEG moiety lowers the clearance of interferon alpha-2a, thereby extending the duration of its therapeutic effects, but may also reduce interferon-mediated stimulation of an immune response. (NCI04)

NCI-GLOSS Definition: A drug used to treat hepatitis C infections. It is also being studied in the treatment and prevention of cancer. It is a cytokine that is modified in the laboratory. It is a type of biological response modifier.

Display Name: Peginterferon Alfa-2a

Label: Peginterferon Alfa-2a

NCI Thesaurus Code: C33987 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0391001  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
PEG-Interferon Alfa-2a
PEG-interferon alfa-2a
Peginterferon Alfa-2a

External Source Codes: 
CAS Registry Number 198153-51-4 (see NLM ChemIDplus info)
FDA UNII Code Q46947FE7K
NSC Code 729130 (see NCI DTP info)
PDQ Closed Trial Search ID 335280
PDQ Open Trial Search ID 335280 (check for NCI PDQ open clinical trial info)
UMLS CUI C0391001

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Chronic hepatitis C; renal cell carcinoma; advanced melanoma; chronic myelogenous leukaemia
Chemical_Formula C10H18N3O5(C2H4O)n(C2H4O)n
code C33987
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name PEG-Interferon_Alfa-2a
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  


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