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Version: 17.06d (Release date: 2017-06-26)
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Calcitriol (Code C330)

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Terms & Properties

Preferred Name: Calcitriol

Definition: A synthetic physiologically-active analog of vitamin D, specifically the vitamin D3 form. Calcitriol regulates calcium in vivo by promoting absorption in the intestine, reabsorption in the kidneys, and, along with parathyroid hormone, regulation of bone growth. A calcitriol receptor-binding protein appears to exist in the mucosa of human intestine. Calcitriol also induces cell cycle arrest at G0/G1 phase of the cell cycle, cell differentiation, and apoptosis, resulting in inhibition of proliferation of some tumor cell types. This agent may be chemopreventive for colon and prostate cancers. (NCI04)

NCI-GLOSS Definition: The active form of vitamin D. Calcitriol is formed in the kidneys or made in the laboratory. It is used as a drug to increase calcium levels in the body in order to treat skeletal and tissue-related calcium deficiencies caused by kidney or thyroid disorders.

Display Name: Calcitriol

Label: Calcitriol

NCI Thesaurus Code: C330 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0006674  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(1alpha,3beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol
1,25(OH)2-D3
1,25-DHCC
1,25-Dihydroxycholecalciferol
1,25-Dihydroxycholecaliferol
Calcijex
Calcitriol
CALCITRIOL
calcitriol
Rocaltrol

External Source Codes: 
CAS Registry Number 32222-06-3 (see NLM ChemIDplus info)
FDA UNII Code FXC9231JVH
ChEBI ID CHEBI:17823 (see ChEBI info)
PDQ Closed Trial Search ID 41919
PDQ Open Trial Search ID 41919 (check for NCI PDQ open clinical trial info)
UMLS CUI C0006674

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Hyperparathyroidism; Hypocalcemia
Chemical_Formula C27H44O3
code C330
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Calcitriol
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C330

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