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Version: 17.06d (Release date: 2017-06-26)
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Caffeine (Code C328)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Caffeine

Definition: A methylxanthine alkaloid found in the seeds, nuts, or leaves of a number of plants native to South America and East Asia that is structurally related to adenosine and acts primarily as an adenosine receptor antagonist with psychotropic and anti-inflammatory activities. Upon ingestion, caffeine binds to adenosine receptors in the central nervous system (CNS), which inhibits adenosine binding. This inhibits the adenosine-mediated downregulation of CNS activity; thus, stimulating the activity of the medullary, vagal, vasomotor, and respiratory centers in the brain. This agent also promotes neurotransmitter release that further stimulates the CNS. The anti-inflammatory effects of caffeine are due the nonselective competitive inhibition of phosphodiesterases (PDEs). Inhibition of PDEs raises the intracellular concentration of cyclic AMP (cAMP), activates protein kinase A, and inhibits leukotriene synthesis, which leads to reduced inflammation and innate immunity.

NCI-GLOSS Definition: A substance found in the leaves and beans of the coffee tree, in tea, yerba mate, guarana berries, and in small amounts in cocoa. It can also be made in the laboratory, and is added to some soft drinks, foods, and medicines. Caffeine increases brain activity, alertness, attention, and energy. It may also increase blood pressure, heart rate, breathing rate, and the loss of water from the body in urine.

CRCH Definition: An alkaloid stimulant having a purine double-ring structure composed of eight carbons and four nitrogen atoms with methyl groups attached to the nitrogen atoms at the 1, 3, and 7 positions and having double bonds at the carbons in positions 2 and 6.

Display Name: Caffeine

Label: Caffeine

NCI Thesaurus Code: C328 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0006644  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1,3,7-trimethylxanthine
3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
CAF
Caffeine
caffeine
CAFFEINE
Methyltheobromine
Theine
Trimethylxanthine

External Source Codes: 
CAS Registry Number 58-08-2 (see NLM ChemIDplus info)
FDA UNII Code 3G6A5W338E
ChEBI ID CHEBI:27732 (see ChEBI info)
NSC Code 5036 (see NCI DTP info)
PDQ Closed Trial Search ID 40817
PDQ Open Trial Search ID 40817 (check for NCI PDQ open clinical trial info)
UMLS CUI C0006644

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C8H10N4O2
code C328
Contributing_Source CRCH
Contributing_Source CTRP
Contributing_Source FDA
INFOODS CAFFN
Legacy_Concept_Name Caffeine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance
Unit mg
USDA_ID 262

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C328

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