|Caffeine (Code C328)|
|Terms & Properties|
Preferred Name: Caffeine
Definition: A methylxanthine alkaloid found in the seeds, nuts, or leaves of a number of plants native to South America and East Asia that is structurally related to adenosine and acts primarily as an adenosine receptor antagonist with psychotropic and anti-inflammatory activities. Upon ingestion, caffeine binds to adenosine receptors in the central nervous system (CNS), which inhibits adenosine binding. This inhibits the adenosine-mediated downregulation of CNS activity; thus, stimulating the activity of the medullary, vagal, vasomotor, and respiratory centers in the brain. This agent also promotes neurotransmitter release that further stimulates the CNS. The anti-inflammatory effects of caffeine are due the nonselective competitive inhibition of phosphodiesterases (PDEs). Inhibition of PDEs raises the intracellular concentration of cyclic AMP (cAMP), activates protein kinase A, and inhibits leukotriene synthesis, which leads to reduced inflammation and innate immunity.
NCI-GLOSS Definition: A substance found in the leaves and beans of the coffee tree, in tea, yerba mate, guarana berries, and in small amounts in cocoa. It can also be made in the laboratory, and is added to some soft drinks, foods, and medicines. Caffeine increases brain activity, alertness, attention, and energy. It may also increase blood pressure, heart rate, breathing rate, and the loss of water from the body in urine.
CRCH Definition: An alkaloid stimulant having a purine double-ring structure composed of eight carbons and four nitrogen atoms with methyl groups attached to the nitrogen atoms at the 1, 3, and 7 positions and having double bonds at the carbons in positions 2 and 6.
Display Name: Caffeine
NCI Metathesaurus Link: C0006644 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
External Source Codes:
|CAS Registry Number||58-08-2 (see NLM ChemIDplus info)|
|FDA UNII Code||3G6A5W338E|
|ChEBI ID||CHEBI:27732 (see ChEBI info)|
|NSC Code||5036 (see NCI DTP info)|
|PDQ Closed Trial Search ID||40817|
|PDQ Open Trial Search ID||40817 (check for NCI PDQ open clinical trial info)|
|Name||Value (qualifiers indented underneath)|
Additional Concept Data:
|Defined Fully by Roles: No|