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Version: 16.11d (Release date: 2016-11-28)
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Busulfan (Code C321)

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Terms & Properties

Preferred Name: Busulfan

Definition: A synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription. (NCI04)

NCI-GLOSS Definition: An anticancer drug that belongs to the family of drugs called alkylating agents.

Display Name: Busulfan

Label: Busulfan

NCI Thesaurus Code: C321 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0700015  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1,4-Bis(methanesulfonoxy)butane
1,4-Bitanediol Dimethanesulfonate Esters
1,4-Butanediol Dimethylsulfonate
1,4-Di(methanesulfonyloxy)butane
1,4-Di(methylsulfonyloxy)butane
1, 4-Bis[methanesulfonoxy]butane
BUS
Bussulfam
Busulfan
BUSULFAN
busulfan
Busulfanum
Busulfex
Busulphan
CB-2041
CB 2041
Glyzophrol
GT-41
GT 41
Joacamine
Methanesulfonic acid, tetramethylene ester
Methanesulfonic Acid Tetramethylene Ester
Mielucin
Misulban
Misulfan
Mitosan
Myeleukon
Myeloleukon
Myelosan
Mylecytan
Myleran
Sulfabutin
Tetramethylene Bis(methanesulfonate)
Tetramethylene bis[methanesulfonate]
WR-19508

External Source Codes: 
CAS Registry Number 55-98-1 (see NLM ChemIDplus info)
FDA UNII Code G1LN9045DK
ChEBI ID CHEBI:28901 (see ChEBI info)
NSC Code 750 (see NCI DTP info)
PDQ Closed Trial Search ID 41947
PDQ Open Trial Search ID 41947 (check for NCI PDQ open clinical trial info)
UMLS CUI C0700015

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Bone marrow disorders; chronic myelogenous leukemia; palliative; neoadjuvant to allogeneic hematopoietic progenitor cell transplantation; neoplastic meningitis; primary brain malignancies
Chemical_Formula C6H14O6S2
code C321
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Busulfan
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C321

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