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Version: 17.06d (Release date: 2017-06-26)
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Buserelin (Code C320)

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Terms & Properties

Preferred Name: Buserelin

Definition: A synthetic analog of gonadotropin-releasing hormone (GnRH). Buserelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Prolonged administration of buserelin results in sustained inhibition of gonadotropin production, suppression of testicular and ovarian steroidogenesis, and reduced levels of circulating gonadotropin and gonadal steroids. Buserelin is more potent that GnRH. (NCI04)

NCI-GLOSS Definition: An anticancer drug that belongs to the family of drugs called gonadotropin-releasing hormones. In prostate cancer therapy, buserelin blocks the production of testosterone in the testicles.

Display Name: Buserelin

Label: Buserelin

NCI Thesaurus Code: C320 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0006456  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
6-[O-(1,1-Dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-10-deglycinamide-luteinizing Hormone-releasing Factor (Pig)
6-[O-(1,1-Dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-10-deglycinamide Luteinizing Hormone-Releasing Factor (Pig)
BSRL
Buserelin
BUSERELIN
buserelin
Busereline
Etilamide
HOE 766
ICI 123215
S74-6766

External Source Codes: 
CAS Registry Number 57982-77-1 (see NLM ChemIDplus info)
FDA UNII Code PXW8U3YXDV
NSC Code 725176 (see NCI DTP info)
PDQ Closed Trial Search ID 39170
PDQ Open Trial Search ID 39170 (check for NCI PDQ open clinical trial info)
UMLS CUI C0006456

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Breast cancer; Contraception, female; Endometriosis; Infertility; in vitro fertilization; Polycystic ovary syndrome; Prostate cancer; Uterine leiomyoma
Chemical_Formula C60H86N16O13
code C320
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Buserelin
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C320

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