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Version: 17.06d (Release date: 2017-06-26)
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Broxuridine (Code C318)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Broxuridine

Definition: A halogenated thymidine analogue with potential antineoplastic and radiosensitizing activities. Bromodeoxyuridine competes with thymidine for incorporation into DNA, resulting in DNA mutation and the inhibition of cell proliferation. As a radiosensitizer, this agent is associated with the inhibition of repair of radiation-induced DNA double-strand breaks.

NCI-GLOSS Definition: A drug that makes cancer cells more sensitive to radiation and is also used as a diagnostic agent to determine how fast cancer cells grow.

Display Name: Broxuridine

Label: Broxuridine

NCI Thesaurus Code: C318 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0006233  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
5-BrdU
5-Bromo-2'-deoxyuridine
5-Bromodeoxyuridine
5-Bromouracil-2-deoxyriboside
5-Bromouracil Deoxyriboside
5-Bromouracil deoxyriboside
5-Budr
BrdU
BRDU
Bromodeoxyuridine
Bromouracil deoxyriboside
Bromouracil Deoxyriboside
Bromouridine
Broxine
Broxuridine
BROXURIDINE
broxuridine
Neomark
Neomark-BU

External Source Codes: 
CAS Registry Number 59-14-3 (see NLM ChemIDplus info)
CAS Registry Number 21597-77-3 (see NLM ChemIDplus info)
FDA UNII Code G34N38R2N1
ChEBI ID CHEBI:472552 (see ChEBI info)
NSC Code 38297 (see NCI DTP info)
PDQ Closed Trial Search ID 39168
PDQ Open Trial Search ID 39168 (check for NCI PDQ open clinical trial info)
UMLS CUI C0006233

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C9H11BrN2O5
code C318
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Bromodeoxyuridine
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C318

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