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Version: 17.10e (Release date: 2017-10-30)
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Bromocriptine Mesylate (Code C317)

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Terms & Properties

Preferred Name: Bromocriptine Mesylate

Definition: The mesylate salt of bromocriptine, a semisynthetic ergot alkaloid with dopaminergic, antidyskinetic, and antiprolactinemic activities. Bromocriptine selectively binds to and activates postsynaptic dopamine D2 receptors in the corpus striatum of the central nervous system (CNS). Activation of these D2 receptors activate inhibitory G-proteins, which inhibit adenylyl cyclase, preventing signal transduction mediated via cAMP and resulting in the inhibition of neurotransmission and an antidyskinetic effect. This agent also stimulates dopamine D2 receptors in the anterior pituitary gland, which results in the inhibition of prolactin secretion and lactation and may inhibit the proliferation of prolactin-dependent breast cancer cells.

Label: Bromocriptine Mesylate

NCI Thesaurus Code: C317 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0546852  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Bromo-alpha-ergocryptine Mesylate
Bromocriptine Mesylate
Ergotaman-3',6',18-trione, 2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-, monomethanesulfonate (salt), (5'alpha)-

External Source Codes: 
CAS Registry Number 22260-51-1 (see NLM ChemIDplus info)
ChEBI ID CHEBI:3182 (see ChEBI info)
PDQ Closed Trial Search ID 39165
PDQ Open Trial Search ID 39165 (check for NCI PDQ open clinical trial info)
UMLS CUI C0546852

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C32H40BrN5O5.CH4O3S
code C317
Contributing_Source FDA
Legacy_Concept_Name Bromocriptine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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