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Version: 17.06d (Release date: 2017-06-26)
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Bleomycin Sulfate (Code C312)

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Terms & Properties

Preferred Name: Bleomycin Sulfate

Definition: A mixture of the sulfate salts of basic glycopeptide antineoplastic antibiotics isolated from Streptomyces verticillus. Bleomycin sulfate forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals which cause single- and double-stranded breaks in DNA; these reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation.

NCI-GLOSS Definition: A drug that is used to treat many types of cancer and is being studied in the treatment of other types of cancer. It comes from the bacterium Streptomyces verticillus. Blenoxane that damages DNA and may kill cancer cells. It is a type of antineoplastic antibiotic.

Display Name: Bleomycin Sulfate

Label: Bleomycin Sulfate

NCI Thesaurus Code: C312 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0701921  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Blanoxan
BleMomycine
Blenoxane
Bleo-cell
Bleo-S
Bleocin
Bleolem
Bleomycini Sulfas
Bleomycin Sulfas
Bleomycin Sulfate
Bleomycin sulfate
BLEOMYCIN SULFATE
bleomycin sulfate
Bleomycin Sulphate
Blexane
Oil Bleo

External Source Codes: 
CAS Registry Number 9041-93-4 (see NLM ChemIDplus info)
FDA UNII Code 7DP3NTV15T
ChEBI ID CHEBI:34582 (see ChEBI info)
PDQ Closed Trial Search ID 39139
PDQ Open Trial Search ID 39139 (check for NCI PDQ open clinical trial info)
UMLS CUI C0701921

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Squamous cell carcinomas of the head and neck; penis; cervix and vulva; Hodgkins and; non-Hodgkins lymphoma; testicular embryonal cell and ovarian carcinoma; chorio- and teratocarcinoma; malignant pleural effusion; melanoma; sarcoma; ovary germ cell tumor
code C312
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Bleomycin_Sulphate
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Antibiotic

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C312

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