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Version: 17.12d (Release date: 2017-12-26)
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Lerisetron (Code C30143)

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Terms & Properties

Preferred Name: Lerisetron

Definition: The hydrochloride salt of a 2-piperazinylbenzimidazole-derivative serotonin type 3 (5-HT3) receptor antagonist with antiemetic activity. Lerisetron specifically binds to 5-HT3 receptors, located peripherally on vagus nerve terminals and centrally in the chemoreceptor trigger zone (CTZ) of the area postrema, which may result in suppression of chemotherapy-induced nausea and vomiting.

NCI-GLOSS Definition: A substance being studied in the treatment of nausea and vomiting caused by cancer treatment. Lerisetron is a type of serotonin receptor antagonist and a type of antiemetic.

Label: Lerisetron

NCI Thesaurus Code: C30143 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0758799  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-Phenyl-Methyl-2-Piperazinyl-1H-Benzimidazole Hydrochloride

External Source Codes: 
CAS Registry Number 143257-98-1 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 37821
PDQ Open Trial Search ID 37821 (check for NCI PDQ open clinical trial info)
UMLS CUI C0758799

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C18H20N4
code C30143
Contributing_Source FDA
Legacy_Concept_Name Lerisetron
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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