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Version: 17.06d (Release date: 2017-06-26)
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Lerisetron (Code C30143)

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Terms & Properties

Preferred Name: Lerisetron

Definition: The hydrochloride salt of a 2-piperazinylbenzimidazole-derivative serotonin type 3 (5-HT3) receptor antagonist with antiemetic activity. Lerisetron specifically binds to 5-HT3 receptors, located peripherally on vagus nerve terminals and centrally in the chemoreceptor trigger zone (CTZ) of the area postrema, which may result in suppression of chemotherapy-induced nausea and vomiting.

NCI-GLOSS Definition: A substance being studied in the treatment of nausea and vomiting caused by cancer treatment. Lerisetron is a type of serotonin receptor antagonist and a type of antiemetic.

Label: Lerisetron

NCI Thesaurus Code: C30143 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0758799  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-Phenyl-Methyl-2-Piperazinyl-1H-Benzimidazole Hydrochloride
F-0930-RS2
lerisetron
LERISETRON
Lerisetron

External Source Codes: 
CAS Registry Number 143257-98-1 (see NLM ChemIDplus info)
FDA UNII Code Q36R82SXRG
PDQ Closed Trial Search ID 37821
PDQ Open Trial Search ID 37821 (check for NCI PDQ open clinical trial info)
UMLS CUI C0758799

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C18H20N4
code C30143
Contributing_Source FDA
Legacy_Concept_Name Lerisetron
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C30143

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