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Version: 16.10e (Release date: 2016-10-31)
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Diphenhydramine Hydrochloride (Code C300)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Diphenhydramine Hydrochloride

Definition: The hydrochloride salt form of diphenhydramine, an ethanolamine and first-generation histamine antagonist with anti-allergic activity. Diphenhydramine hydrochloride competitively blocks H1receptors, thereby preventing the actions of histamine on bronchial smooth muscle, capillaries, and gastrointestinal (GI) smooth muscle. This prevents histamine-induced bronchoconstriction, vasodilation, increased capillary permeability, and GI smooth muscle spasms.

Display Name: Diphenhydramine Hydrochloride

Label: Diphenhydramine Hydrochloride

NCI Thesaurus Code: C300 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0004963  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Benadryl
Bendylate
Diphenhydramine.HCl
Diphenhydramine Hydrochloride
DIPHENHYDRAMINE HYDROCHLORIDE
Diphenhydramine hydrochloride
Eldadryl
SK-Diphenhydramine

External Source Codes: 
CAS Registry Number 147-24-0 (see NLM ChemIDplus info)
FDA UNII Code TC2D6JAD40
ChEBI ID CHEBI:4637 (see ChEBI info)
NSC Code 33299 (see NCI DTP info)
PDQ Closed Trial Search ID 39163
PDQ Open Trial Search ID 39163 (check for NCI PDQ open clinical trial info)
UMLS CUI C0004963

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C17H21NO.HCl
code C300
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Diphenhydramine_Hydrochloride
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C300

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