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Version: 17.06d (Release date: 2017-06-26)
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Ibritumomab Tiuxetan (Code C29981)

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Terms & Properties

Preferred Name: Ibritumomab Tiuxetan

Definition: An immunoconjugate of the monoclonal antibody ibritumomab conjugated with the linker-chelator tiuxetan, a high affinity, conformationally restricted chelation site for radioisotopes. When bound to indium In 111 or yttrium Y 90, ibritumomab tiuxetan, targeting the CD20 antigen on B cell surfaces, specifically delivers a potentially cytotoxic dose of radiation to B lymphocytes. Ibritumomab is a murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes.

NCI-GLOSS Definition: A monoclonal antibody that is used to treat certain types of B-cell non-Hodgkin lymphoma and is being studied in the treatment and detection of other types of B-cell tumors. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. Ibritumomab binds to the protein called CD20, which is found on B cells. It is linked to the compound tiuxetan. This allows certain radioisotopes to be attached before it is given to a patient. It is a type of monoclonal antibody-chelator conjugate.

Display Name: Ibritumomab Tiuxetan

Label: Ibritumomab Tiuxetan

NCI Thesaurus Code: C29981 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0877880  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ibritumomab Tiuxetan
IBRITUMOMAB TIUXETAN
ibritumomab tiuxetan
IDEC-129
IDEC-2B8
Zevalin

External Source Codes: 
CAS Registry Number 206181-63-7 (see NLM ChemIDplus info)
FDA UNII Code 4Q52C550XK
PDQ Closed Trial Search ID 43080
PDQ Open Trial Search ID 43080 (check for NCI PDQ open clinical trial info)
UMLS CUI C0877880

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C23H32N5O10S
code C29981
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Ibritumomab_Tiuxetan
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C29981

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