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Version: 17.06d (Release date: 2017-06-26)
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Rebamipide (Code C29852)

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Terms & Properties

Preferred Name: Rebamipide

Definition: A quinolinone derivative with anti-ulcer and anti-inflammatory activities. Rebamipide induces cyclooxygenase 2 (COX2) synthesis which results in an increase in endogenous prostaglandin synthesis in the gastric mucosa. This agent also inhibits H. pylori-induced production of tumor necrosis factor (TNF) alpha and subsequent inflammation of the gastric mucosa. In addition, rebamipide scavenges oxygen-derived free radicals that potentially cause mucosal injury, and stimulates prostaglandin EP4 receptor gene expression followed by mucous secretion, thereby enhancing the gastric mucosal defense.

Label: Rebamipide

NCI Thesaurus Code: C29852 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0069562  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
alpha-[(4-Chlorobenzoyl)amino]-1,2-dihydro-2-oxo-4-quinolinepropanoic Acid
OPC 12759

External Source Codes: 
CAS Registry Number 90098-04-7 (see NLM ChemIDplus info)
CAS Registry Number 111911-87-6 (see NLM ChemIDplus info)
UMLS CUI C0069562

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C19H15ClN2O4
code C29852
Contributing_Source FDA
Legacy_Concept_Name Rebamipide
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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