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Version: 16.11d (Release date: 2016-11-28)
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Dihydrotestosterone (Code C29619)

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Terms & Properties

Preferred Name: Dihydrotestosterone

Definition: The most potent androgen, required for sex development. Dihydrotestosterone is synthesized from testosterone in the prostate gland, testes, hair follicles and adrenal glands by 5-alpha reductase. Dihydrotestosterone exerts its action similar to testosterone, which binds to and activates specific nuclear androgen receptors. After translocation into the nucleus, the activated hormone-receptor complex binds to the androgen response elements on the DNA and activates gene expressions that are required for sex development. Dihydrotestosterone is responsible for the formation of male primary sex characteristics and most male secondary sex characteristics during puberty, such as muscular growth, facial and body hair growth, and deepening of the voice.

NCI-GLOSS Definition: A hormone made from testosterone in the prostate, testes, and certain other tissues. It is needed to develop and maintain male sex characteristics, such as facial hair, deep voice, and muscle growth. High amounts of androstanolone may increase the growth of prostate cancer and make it harder to treat.

Label: Dihydrotestosterone

NCI Thesaurus Code: C29619 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL414312  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(5alpha,17beta)-17-Hydroxyandrostan-3-one
Androstanolone
androstanolone
DHT
Dihydrotestosterone
dihydrotestosterone

External Source Codes: 
NCI META CUI CL414312

Other Properties:
Name Value (qualifiers indented underneath)
code C29619
Legacy_Concept_Name Androstanolone
Semantic_Type Hormone
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C29619

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