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Version: 17.06d (Release date: 2017-06-26)
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Zolpidem Tartrate (Code C29553)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Zolpidem Tartrate

Definition: The tartrate salt of an imidazopyridine with non-benzodiazepine benzodiazepine-receptor agonist and sedative-hypnotic activities. Zolpidem binds selectively to the alpha 1 subunit of the omega-1 (BZ1) receptor of the gamma-aminobutyric acid type A (GABA-A) receptor-chloride ionophore complex, thereby opening neuronal chloride channels, hyperpolarizing neuronal cell membranes, and inhibiting neuronal firing. In contrast, benzodiazepines non-selectively bind to and activate all omega receptor subtypes, exhibiting anticonvulsant and myorelaxant activities in addition to a sedative-hypnotic activity.

NCI-GLOSS Definition: A drug used to treat insomnia (inability to sleep), and anxiety. It is a type of imidazopyridine (sedative hypnotic).

Label: Zolpidem Tartrate

NCI Thesaurus Code: C29553 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0724725  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ambien
Intermezzo
zolpidem
Zolpidem Tartrate
ZOLPIDEM TARTRATE

External Source Codes: 
CAS Registry Number 99294-93-6 (see NLM ChemIDplus info)
FDA UNII Code WY6W63843K
ChEBI ID CHEBI:10126 (see ChEBI info)
PDQ Closed Trial Search ID 370808
PDQ Open Trial Search ID 370808 (check for NCI PDQ open clinical trial info)
UMLS CUI C0724725

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula 2C19H21N3O.C4H6O6
code C29553
Contributing_Source FDA
Legacy_Concept_Name Zolpidem_Tartrate
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C29553

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