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Version: 16.11d (Release date: 2016-11-28)
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Valproic Acid (Code C29536)

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Terms & Properties

Preferred Name: Valproic Acid

Definition: A synthetic derivative of propylpentanoic acid with antiepileptic properties and potential antineoplastic and antiangiogenesis activities. In epilepsy, valproic acid appears to act by increasing the concentration of gamma-aminobutyric acid (GABA) in the brain. This agent's antitumor and antiangiogenesis activities may be related to the inhibition of histone deacetylases and nitric oxide synthase, which results in the inhibition of nitric oxide synthesis. (NCI04)

NCI-GLOSS Definition: A drug used to treat epileptic seizures and bipolar disorder and to prevent migraine headaches. It is also being studied in the treatment of several types of cancer. It blocks an enzyme that cells need to grow and may cause cancer cells to die. It also blocks the growth of new blood vessels that tumors need to grow. It is a type of anticonvulsant, histone deacetylase (HDAC) inhibitor, antimaniacal, migraine headache prophylactic, and antiangiogenesis agent.

Display Name: Valproic Acid

Label: Valproic Acid

NCI Thesaurus Code: C29536 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0042291  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Propylpentanoic Acid
2-Propylvaleric Acid
Depakene
Di-n-propylacetic Acid
Stavzor
Valproate
Valproic Acid
VALPROIC ACID
valproic acid

External Source Codes: 
CAS Registry Number 99-66-1 (see NLM ChemIDplus info)
FDA UNII Code 614OI1Z5WI
ChEBI ID CHEBI:39867 (see ChEBI info)
NSC Code 93819 (see NCI DTP info)
PDQ Closed Trial Search ID 350047
PDQ Open Trial Search ID 350047 (check for NCI PDQ open clinical trial info)
UMLS CUI C0042291

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Epilepsy; Mania; Migraine
Chemical_Formula C8H16O2
code C29536
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Valproic_Acid
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C29536

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