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Version: 17.06d (Release date: 2017-06-26)
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Bacitracin (Code C295)

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Terms & Properties

Preferred Name: Bacitracin

Definition: A complex of cyclic polypeptide antibiotics, mainly bacitracin A, produced by spore-forming organisms belonging to the licheniformin group of the Bacillus subtilis with antibacterial activity. Bacitracin binds to C55-isoprenyl pyrophosphate, a biphosphate lipid transport molecule that carries the building blocks of the peptidoglycan bacterial cell wall. The binding interferes with the enzymatic dephosphorylation of the C55-isoprenyl pyrophosphate and prevents peptidoglycan synthesis, thereby inhibiting bacterial cell growth.

Label: Bacitracin

NCI Thesaurus Code: C295 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0004599  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BACITRACIN
Bacitracin

External Source Codes: 
CAS Registry Number 1405-87-4 (see NLM ChemIDplus info)
FDA UNII Code 58H6RWO52I
ChEBI ID CHEBI:28669 (see ChEBI info)
NSC Code 45737 (see NCI DTP info)
PDQ Closed Trial Search ID 42858
PDQ Open Trial Search ID 42858 (check for NCI PDQ open clinical trial info)
UMLS CUI C0004599

Other Properties:
     Name Value (qualifiers indented underneath)
code C295
Contributing_Source FDA
Legacy_Concept_Name Bacitracin
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Antibiotic

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C295

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