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Version: 16.10e (Release date: 2016-10-31)
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Tazarotene (Code C29487)

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Terms & Properties

Preferred Name: Tazarotene

Definition: A synthetic, topical retinoid. Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. In psoriasis, tazarotene normalizes abnormal keratinocyte differentiation and reduces their hyperproliferation. (NCI04)

NCI-GLOSS Definition: A drug used on the skin to treat several skin conditions. It is also being studied in the treatment of basal cell skin cancer and basal cell nevus syndrome. Tazarotene is related to vitamin A and is made in the laboratory. It turns on a gene that may help stop the growth of skin cancer cells. Tazarotene is a type of synthetic retinoid.

Display Name: Tazarotene

Label: Tazarotene

NCI Thesaurus Code: C29487 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0288792  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
6-[(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]- 3-Pyridinecarboxylic Acid, Ethyl Ester
AGN-190168
Avage
Ethyl 6-(2-(4,4-Dimethylthiochroman-6-yl)ethynyl)nicotinate
Tazarotene
TAZAROTENE
tazarotene
Tazorac

External Source Codes: 
CAS Registry Number 118292-40-3 (see NLM ChemIDplus info)
FDA UNII Code 81BDR9Y8PS
ChEBI ID CHEBI:32184 (see ChEBI info)
PDQ Closed Trial Search ID 553530
PDQ Open Trial Search ID 553530 (check for NCI PDQ open clinical trial info)
UMLS CUI C0288792

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Topical treatment of facial acne vulgaris; stable plaque psoriasis; mitigation (palliation) of facial fine wrinkling; facial mottled hyper- and hypopigmentation; benign facial lentigines
Chemical_Formula C21H21NO2S
code C29487
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Tazarotene
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C29487

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