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Version: 17.06d (Release date: 2017-06-26)
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TGFa-PE38 Immunotoxin (Code C29483)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: TGFa-PE38 Immunotoxin

Definition: A recombinant, chimeric toxin composed of human transforming growth factor alpha (TGF-alpha) fused to a fragment of Pseudomonas exotoxin (PE38) without its cell-binding domain. The TGF-alpha moiety of the agent attaches to tumor cells expressing the epithelial growth factor receptor (EGFR); the exotoxin induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also catalyzes the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, thereby inactivating elongation factor 2 and inhibiting protein synthesis. (NCI04)

NCI-GLOSS Definition: A substance being studied in the treatment of brain tumors. It combines a protein that binds to certain tumor cells with a bacterial toxin that kills tumor cells.

Label: TGFa-PE38 Immunotoxin

NCI Thesaurus Code: C29483 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1328109  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Cervene
TGFa-PE38 Immunotoxin
TP-38
TP-38 immunotoxin

External Source Codes: 
NSC Code 726586 (see NCI DTP info)
PDQ Closed Trial Search ID 346468
PDQ Open Trial Search ID 346468 (check for NCI PDQ open clinical trial info)
UMLS CUI C1328109

Other Properties:
     Name Value (qualifiers indented underneath)
code C29483
Legacy_Concept_Name TP-38
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C29483

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