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Version: 17.06d (Release date: 2017-06-26)
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Simvastatin (Code C29454)

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Terms & Properties

Preferred Name: Simvastatin

Definition: A lipid-lowering agent derived synthetically from a fermentation product of the fungus Aspergillus terreus. Hydrolyzed in vivo to an active metabolite, simvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. (NCI04)

Display Name: Simvastatin

Label: Simvastatin

NCI Thesaurus Code: C29454 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0074554  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
[1S-[1alpha,3alpha,7beta,8beta(2S*,4S*),8abeta]]-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl 2,2-dimethylbutanoate
MK 733

External Source Codes: 
CAS Registry Number 79902-63-9 (see NLM ChemIDplus info)
ChEBI ID CHEBI:9150 (see ChEBI info)
NSC Code 633782 (see NCI DTP info)
PDQ Closed Trial Search ID 455226
PDQ Open Trial Search ID 455226 (check for NCI PDQ open clinical trial info)
UMLS CUI C0074554

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C25H38O5
code C29454
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Simvastatin
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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