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Version: 17.06d (Release date: 2017-06-26)
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DNA Minor Groove Binding Agent SG2000 (Code C29435)

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Terms & Properties

Preferred Name: DNA Minor Groove Binding Agent SG2000

Definition: A sequence-selective pyrrolobenzodiazepine (PBD) dimer with potential antineoplastic activity. Following intravenous administration, DNA minor groove binding agent SG2000 preferentially and covalently binds to purine-GATC-pyrimidine sequences, with the imine/carbinolamine moieties of SG2000 binding to the N2 positions of guanines on opposite strands of DNA. This induces interstrand cross-links and inhibits both DNA replication and gene transcription, which lead to the inhibition of cell growth. With a preference for binding to purine-GATC-pyrimidine sequences, SG2000 adducts do not appear to be susceptible to p53-mediated DNA excision repair.

NCI-GLOSS Definition: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called DNA cross-linking agents.

Display Name: DNA Minor Groove Binding Agent SG2000

Label: DNA Minor Groove Binding Agent SG2000

NCI Thesaurus Code: C29435 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1519143  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(11aS,11a'S)-8,8'-(propane-1,3-diylbis(oxy))bis(7-methoxy-2-methylene-2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one)
BN2629
DNA Minor Groove Binding Agent SG2000
NSC 694501
Pyrrolobenzodiazepine Dimer
SG2000
SJG-136
SJG136

External Source Codes: 
CAS Registry Number 232931-57-6 (see NLM ChemIDplus info)
NSC Code 694501 (see NCI DTP info)
PDQ Closed Trial Search ID 415963
PDQ Open Trial Search ID 415963 (check for NCI PDQ open clinical trial info)
UMLS CUI C1519143

Other Properties:
     Name Value (qualifiers indented underneath)
code C29435
Contributing_Source CTRP
Legacy_Concept_Name SJG-136
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C29435

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