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Version: 17.06d (Release date: 2017-06-26)
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Ramipril (Code C29411)

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Terms & Properties

Preferred Name: Ramipril

Definition: A prodrug and nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Ramipril is converted in the liver by de-esterification into its active form ramiprilat, which inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. This agent also causes an increase in bradykinin levels and a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis.

Display Name: Ramipril

Label: Ramipril

NCI Thesaurus Code: C29411 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0072973  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Altace
Ramipril
RAMIPRIL

External Source Codes: 
CAS Registry Number 87333-19-5 (see NLM ChemIDplus info)
FDA UNII Code L35JN3I7SJ
ChEBI ID CHEBI:8774 (see ChEBI info)
PDQ Closed Trial Search ID 686948
PDQ Open Trial Search ID 686948 (check for NCI PDQ open clinical trial info)
UMLS CUI C0072973

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C23H32N2O5
code C29411
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Ramipril
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C29411

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