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Version: 17.06d (Release date: 2017-06-26)
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Rabeprazole (Code C29410)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Rabeprazole

Definition: An alpha-pyridylmethylsulfinyl benzimidazole and a selective and irreversible proton pump inhibitor with antisecretory property. Rabeprazole enters the parietal cell and accumulates in the acidic secretory canaliculi where the agent is activated by a proton-catalyzed process that results in the formation of a thiophilic sulfonamide or sulfenic acid. The activated rabeprazole forms covalent bonds with the sulfhydryl amino acids cysteine on the extracellular domain of the proton pump (H+/K+ ATPase) at the secretory surface, thereby inhibiting the transport of hydrogen ions, via exchange with potassium ions, into the gastric lumen. Binding to cysteine 813, in particular, is essential for inhibition of gastric acid production.

Label: Rabeprazole

NCI Thesaurus Code: C29410 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0378482  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-(((4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole
LY307640
Rabeprazole
RABEPRAZOLE

External Source Codes: 
CAS Registry Number 117976-89-3 (see NLM ChemIDplus info)
FDA UNII Code 32828355LL
ChEBI ID CHEBI:8768 (see ChEBI info)
UMLS CUI C0378482

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C18H21N3O3S
code C29410
Contributing_Source FDA
Legacy_Concept_Name Rabeprazole
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C29410

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