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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Pioglitazone Hydrochloride (Code C29367)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Pioglitazone Hydrochloride

Definition: The hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Pioglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation. (NCI05)

NCI-GLOSS Definition: A drug that is used to treat type 2 diabetes and is being studied in the prevention of head and neck cancer. It may be able to stop leukoplakia (a condition affecting the mouth) from developing into cancer. It is a type of thiazolidinedione.

Display Name: Pioglitazone Hydrochloride

Label: Pioglitazone Hydrochloride

NCI Thesaurus Code: C29367 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0872972  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Pioglitazone Hydrochloride

External Source Codes: 
CAS Registry Number 112529-15-4 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 398145
PDQ Open Trial Search ID 398145 (check for NCI PDQ open clinical trial info)
UMLS CUI C0872972

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C19H20N2O3S.HCl
code C29367
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Pioglitazone
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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