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Version: 17.06d (Release date: 2017-06-26)
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Talotrexin (Code C29341)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Talotrexin

Definition: An antimetabolite analogue of aminopterin with potential antineoplastic activity. As a folate antagonist, talotrexin binds to and inhibits the function of dihydrofolate reductase, resulting in the inhibition of folate metabolism, DNA synthesis, and cell division. Hydrosoluble, talotrexin is actively transported into cells by the reduced folate carrier (RFC) and, therefore, is unlikely to be associated with P-glycoprotein-mediated multidrug resistance.

NCI-GLOSS Definition: A substance that is being studied in the treatment of leukemia and some other types of cancer. It belongs to the family of drugs called antifolates.

Label: Talotrexin

NCI Thesaurus Code: C29341 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0251361  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
N(alpha)-(4-Amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine
PT523
Talopterin
TALOTREXIN
talotrexin
Talotrexin

External Source Codes: 
CAS Registry Number 113857-87-7 (see NLM ChemIDplus info)
FDA UNII Code A8E516A20K
NSC Code 623017 (see NCI DTP info)
UMLS CUI C0251361

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C27H27N9O6
code C29341
Contributing_Source FDA
Legacy_Concept_Name PT523
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C29341

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