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Version: 17.06d (Release date: 2017-06-26)
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Inalimarev (Code C29317)

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Terms & Properties

Preferred Name: Inalimarev

Definition: A cancer vaccine comprised of a recombinant vaccinia viral vector encoding the carcinoembryonic antigen (CEA), MUC-1 (mucin-1), a transmembrane glycoprotein secreted by glandular tissues, and TRICOM, comprised of the three co-stimulatory molecule transgenes B7-1, ICAM-1 and LFA-3. Upon administration, inalimarev may enhance CEA and MUC-1 presentation to antigen presenting cells (APC) and may activate a cytotoxic T lymphocyte (CTL) response against CEA- and MUC-1-expressing tumor cells.

NCI-GLOSS Definition: A cancer vaccine made with a form of vaccinia virus that does not cause disease in humans. It is being studied in the treatment of some types of cancer. The virus is changed in the laboratory to make human proteins, including the tumor markers called CEA and MUC-1, that may help immune cells in the body kill tumor cells.

Display Name: Inalimarev

Label: Inalimarev

NCI Thesaurus Code: C29317 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1541349  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
recombinant vaccinia-CEA-MUC-1-TRICOM vaccine
rVaccinia-CEA(D609)/MUC1(L93)/TRICOM Vaccine
Vaccinia-CEA-MUC1-TRICOM Vaccine

External Source Codes: 
CAS Registry Number 685563-13-7 (see NLM ChemIDplus info)
NSC Code 727026 (see NCI DTP info)
PDQ Closed Trial Search ID 385666
PDQ Open Trial Search ID 385666 (check for NCI PDQ open clinical trial info)
UMLS CUI C1541349

Other Properties:
     Name Value (qualifiers indented underneath)
code C29317
Contributing_Source CTRP
Legacy_Concept_Name rVaccinia-CEA_D609_MUC1_L93_TRICOM
Semantic_Type Pharmacologic Substance
Semantic_Type Virus

Additional Concept Data: 
Defined Fully by Roles: No  


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