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Version: 17.06d (Release date: 2017-06-26)
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Falimarev (Code C29316)

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Terms & Properties

Preferred Name: Falimarev

Definition: A cancer vaccine comprised of a recombinant fowlpox viral vector encoding the carcinoembryonic antigen (CEA), MUC-1, a transmembrane glycoprotein secreted by glandular epithelial tissues, and TRICOM, comprised of three co-stimulatory molecule transgenes (B7-1, ICAM-1 and LFA-3). This agent may enhance CEA and MUC-1 presentation to antigen-presenting cells (APC) and may activate a cytotoxic T-cell response against CEA- and MUC-1-expressing tumor cells.

NCI-GLOSS Definition: A cancer vaccine made with a form of a chicken virus that does not cause disease in humans. It is being studied in the treatment of some types of cancer. The virus is changed in the laboratory to make human proteins that may help immune cells in the body kill tumor cells.

Display Name: Falimarev

Label: Falimarev

NCI Thesaurus Code: C29316 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1541350  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Falimarev
falimarev
fCEA-MUC-1-TRI
Fowlpox-CEA(D609)-MUC1(L93)-TRICOM Vaccine
Fowlpox-CEA-MUC-1-TRICOM
PANVAC-F
recombinant fowlpox-CEA-MUC-1-TRICOM vaccine
rFowlpox-CEA(D609)/MUC1(L93)/TRICOM Vaccine

External Source Codes: 
CAS Registry Number 685563-14-8 (see NLM ChemIDplus info)
NSC Code 727027 (see NCI DTP info)
PDQ Closed Trial Search ID 385667
PDQ Open Trial Search ID 385667 (check for NCI PDQ open clinical trial info)
UMLS CUI C1541350

Other Properties:
     Name Value (qualifiers indented underneath)
code C29316
Contributing_Source CTRP
Legacy_Concept_Name rFowlpox-CEA_D609_MUC1_L93_TRICOM
Semantic_Type Pharmacologic Substance
Semantic_Type Virus

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C29316

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