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National Cancer Institute
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Version: 17.12d (Release date: 2017-12-26)
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Nitroglycerin (Code C29294)

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Terms & Properties

Preferred Name: Nitroglycerin

Definition: An organic nitrate with vasodilator activity. Nitroglycerin is converted into nitric oxide (NO) in smooth muscle and activates guanylyl cyclase, thereby increasing cGMP concentration, and resulting in smooth muscle relaxation. Dilatation of the veins results in decreased venous return to the heart, thereby decreasing left ventricular volume (reduced preload) and decreasing myocardial oxygen requirements. Arteriolar relaxation reduces arteriolar resistance (reduced afterload), thereby decreasing myocardial oxygen demands. In addition, nitroglycerine causes coronary artery dilatation, thereby improving myocardial blood distribution.

NCI-GLOSS Definition: In medicine, a substance used as a drug to treat certain heart conditions and to widen the openings in blood vessels. Nitroglycerin is being studied as a way to help chemotherapy work better by making tumor cells more sensitive to the drugs. It is a type of vasodilator.

Display Name: Nitroglycerin

Label: Nitroglycerin

NCI Thesaurus Code: C29294 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0017887  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
CAS Registry Number 55-63-0 (see NLM ChemIDplus info)
ChEBI ID CHEBI:28787 (see ChEBI info)
PDQ Closed Trial Search ID 587505
PDQ Open Trial Search ID 587505 (check for NCI PDQ open clinical trial info)
UMLS CUI C0017887

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Anal Fissure and Fistula
Chemical_Formula C3H5N3O9
code C29294
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Nitroglycerin
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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