skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.08d (Release date: 2017-08-28)
SearchBox Top
SearchBox Bottom
Nadolol (Code C29280)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Nadolol

Definition: A non-selective beta-adrenergic antagonist with antihypertensive and antiarrhythmic activities. Nadolol competitively blocks beta-1 adrenergic receptors located in the heart and vascular smooth muscle, inhibiting the activities of the catecholamines epinephrine and norepinephrine and producing negative inotropic and chronotropic effects. This agent exhibits antiarrhythmic activity via the impairment of atrioventricular (AV) node conduction and a corresponding reduction in sinus rate. In the kidney, inhibition of the beta-2 receptor within the juxtaglomerular apparatus results in the inhibition of renin production and a subsequent reduction in angiotensin II and aldosterone levels, thus inhibiting angiotensin II-dependent vasoconstriction and aldosterone-dependent water retention.

Label: Nadolol

NCI Thesaurus Code: C29280 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0027302  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Corgard
Nadolol
NADOLOL

External Source Codes: 
CAS Registry Number 42200-33-9 (see NLM ChemIDplus info)
FDA UNII Code FEN504330V
ChEBI ID CHEBI:7444 (see ChEBI info)
PDQ Closed Trial Search ID 659002
PDQ Open Trial Search ID 659002 (check for NCI PDQ open clinical trial info)
UMLS CUI C0027302

Other Properties:
     Name Value (qualifiers indented underneath)
code C29280
Contributing_Source FDA
Legacy_Concept_Name Nadolol
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C29280

Mainbox Bottom