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Version: 17.06d (Release date: 2017-06-26)
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Mometasone Furoate (Code C29268)

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Terms & Properties

Preferred Name: Mometasone Furoate

Definition: The furoate salt form of mometasone, a synthetic topical glucocorticosteroid receptor agonist with anti-inflammatory, anti-pruritic and vasoconstrictive properties. Mometasone furoate exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. This results in synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators.. Specifically, mometasone furoate appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from phospholipid membrane by phospholipase A2.

NCI-GLOSS Definition: A drug that is used in a cream to treat certain skin conditions and in a nasal spray to treat sinus problems caused by allergies. It is being studied as a way to treat inflammation of the skin caused by radiation therapy. Elocon is a type of corticosteroid.

Display Name: Mometasone Furoate

Label: Mometasone Furoate

NCI Thesaurus Code: C29268 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0066700  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(11beta,16alpha)-9,21-Dichloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione
Elocon
Mometasone Furoate
MOMETASONE FUROATE
mometasone furoate
Nasonex
Propel
Sch-32088

External Source Codes: 
CAS Registry Number 83919-23-7 (see NLM ChemIDplus info)
FDA UNII Code 04201GDN4R
ChEBI ID CHEBI:47564 (see ChEBI info)
PDQ Closed Trial Search ID 531049
PDQ Open Trial Search ID 531049 (check for NCI PDQ open clinical trial info)
UMLS CUI C0066700

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Sinusitis
Chemical_Formula C27H30Cl2O6
code C29268
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Mometasone_Furoate
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C29268

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