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Version: 17.08d (Release date: 2017-08-28)
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Mirtazapine (Code C29265)

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Terms & Properties

Preferred Name: Mirtazapine

Definition: A synthetic tetracyclic derivative of the piperazino-azepines with antidepressant activity. Although its mechanism of action is unknown, mirtazapine enhances central adrenergic and serotonergic transmission, possibly by acting as an antagonist at central presynaptic alpha 2 adrenergic inhibitory autoreceptors and heteroreceptors. This agent is a potent antagonist of 5-hydroxytryptamine type 2 (5-HT2), 5-HT3, and histamine 1 (H1) receptors, and a moderate antagonist of peripheral alpha 1 adrenergic and muscarinic receptors.

NCI-GLOSS Definition: A drug used to treat depression. It belongs to the family of drugs called antidepressant agents.

Display Name: Mirtazapine

Label: Mirtazapine

NCI Thesaurus Code: C29265 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0049506  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
CAS Registry Number 85650-52-8 (see NLM ChemIDplus info)
CAS Registry Number 61337-67-5 (see NLM ChemIDplus info)
FDA UNII Code A051Q2099Q
ChEBI ID CHEBI:6950 (see ChEBI info)
PDQ Closed Trial Search ID 559298
PDQ Open Trial Search ID 559298 (check for NCI PDQ open clinical trial info)
UMLS CUI C0049506

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C17H19N3
code C29265
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Mirtazapine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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