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Version: 17.06d (Release date: 2017-06-26)
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Losartan Potassium (Code C29165)

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Terms & Properties

Preferred Name: Losartan Potassium

Definition: The potassium salt of losartan, a non-peptide angiotensin II receptor antagonist with antihypertensive activity. Losartan selectively and competitively binds to the angiotensin II receptor (type AT1) and blocks the binding of angiotensin II to the receptor, thus promoting vasodilatation and counteracting the effects of aldosterone. Converted from angiotensin I by angiotensin-converting enzyme (ACE), angiotensin II stimulates the adrenal cortex to synthesize and secrete aldosterone, decreasing sodium excretion and increasing potassium excretion, and acts as a vasoconstrictor in vascular smooth muscle.

NCI-GLOSS Definition: A drug used to treat high blood pressure. Cozaar blocks the action of chemicals that make blood vessels constrict (get narrower). It is a type of angiotensin II receptor antagonist.

Display Name: Losartan Potassium

Label: Losartan Potassium

NCI Thesaurus Code: C29165 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0700492  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol, Monopotassium Salt
Losartan Potassium
losartan potassium

External Source Codes: 
CAS Registry Number 124750-99-8 (see NLM ChemIDplus info)
FDA UNII Code 3ST302B24A
PDQ Closed Trial Search ID 640981
PDQ Open Trial Search ID 640981 (check for NCI PDQ open clinical trial info)
UMLS CUI C0700492

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C22H22ClN6O.K
code C29165
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Losartan_Potassium
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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