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Version: 17.06d (Release date: 2017-06-26)
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Loratadine (Code C29162)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Loratadine

Definition: A piperidine histamine H1-receptor antagonist with anti-allergic properties and without sedative effects. Loratadine blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial smooth muscle, and gastrointestinal smooth muscle, including vasodilatation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscle. Loratadine does not cross the blood-brain barrier and does not cause central nervous system effects.

Label: Loratadine

NCI Thesaurus Code: C29162 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0065180  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-, Ethyl Ester

External Source Codes: 
CAS Registry Number 79794-75-5 (see NLM ChemIDplus info)
NSC Code 721075 (see NCI DTP info)
UMLS CUI C0065180

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C22H23ClN2O2
code C29162
Contributing_Source FDA
Legacy_Concept_Name Loratadine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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