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Version: 17.06d (Release date: 2017-06-26)
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Lisinopril (Code C29159)

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Terms & Properties

Preferred Name: Lisinopril

Definition: An orally bioavailable, long-acting angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Lisinopril, a synthetic peptide derivative, specifically and competitively inhibits ACE, which results in a decrease in the production of the potent vasoconstrictor angiotensin II and, so, diminished vasopressor activity. In addition, angiotensin II-stimulated aldosterone secretion by the adrenal cortex is decreased which results in a decrease in sodium and water retention and an increase in serum potassium.

NCI-GLOSS Definition: A drug used to treat high blood pressure and certain heart conditions. It is also being studied in the prevention and treatment of side effects caused by some anticancer drugs. It blocks certain enzymes that cause blood vessels to constrict (narrow). It is a type of angiotensin-converting enzyme (ACE) inhibitor.

Display Name: Lisinopril

Label: Lisinopril

NCI Thesaurus Code: C29159 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0065374  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
N2-[(1S)-1-Carboxy-3-phenylpropyl]-L-lysyl-L-proline, Dihydrate

External Source Codes: 
CAS Registry Number 83915-83-7 (see NLM ChemIDplus info)
ChEBI ID CHEBI:6503 (see ChEBI info)
PDQ Closed Trial Search ID 658710
PDQ Open Trial Search ID 658710 (check for NCI PDQ open clinical trial info)
UMLS CUI C0065374

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C21H31N3O5.2H2O
code C29159
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Lisinopril
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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