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Version: 16.11d (Release date: 2016-11-28)
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Ketamine Hydrochloride (Code C29142)

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Terms & Properties

Preferred Name: Ketamine Hydrochloride

Definition: The hydrochloride salt of a synthetic derivative of cyclohexanone with analgesic and anesthetic activities. Although its mechanism of action is not well understood, ketamine appears to non-competitively block N-methyl-D-aspartate (NMDA) receptors and may interact with opioid mu receptors and sigma receptors, thereby reducing pain perception, inducing sedation, and producing dissociative anesthesia.

NCI-GLOSS Definition: A drug used to cause a loss of feeling and awareness and to induce sleep in patients having surgery. It is also being studied in the treatment of nerve pain caused by chemotherapy. Ketalar blocks pathways to the brain that are involved in sensing pain. It is a type of general anesthetic.

Display Name: Ketamine Hydrochloride

Label: Ketamine Hydrochloride

NCI Thesaurus Code: C29142 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0700541  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ketalar
Ketamine HCl
Ketamine Hydrochloride
KETAMINE HYDROCHLORIDE
ketamine hydrochloride

External Source Codes: 
CAS Registry Number 1867-66-9 (see NLM ChemIDplus info)
FDA UNII Code O18YUO0I83
ChEBI ID CHEBI:650657 (see ChEBI info)
PDQ Closed Trial Search ID 452041
PDQ Open Trial Search ID 452041 (check for NCI PDQ open clinical trial info)
UMLS CUI C0700541

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C13H16ClNO.HCl
code C29142
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Ketamine_Hydrochloride
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C29142

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