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Version: 17.06d (Release date: 2017-06-26)
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Imexon (Code C29115)

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Terms & Properties

Preferred Name: Imexon

Definition: A 2-cyanoaziridine derivative with antitumor activity in multiple myeloma. Although its mechanism of action is not clearly known, imexon may induce apoptosis via a pathway involving cleaved caspase-3, caspase-9, and/or caspase-8. Other cytotoxic mechanisms of action of this agent may involve thiol depletion, generation of reactive oxygen species (ROS), and decreases in the mitochondrial membrane potential. (NCI04)

NCI-GLOSS Definition: A substance that is being studied in the treatment of some types of cancer, including pancreatic, lung, breast, prostate, melanoma, and multiple myeloma. It belongs to the family of drugs called cyanoaziridine derivatives.

Display Name: Imexon

Label: Imexon

NCI Thesaurus Code: C29115 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0097147  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-imino-1,3-diazabicyclo[3,1,0]-hexan-2-one
Amplimexon
Imexon
imexon
IMEXON

External Source Codes: 
CAS Registry Number 59643-91-3 (see NLM ChemIDplus info)
FDA UNII Code 8F63U28T2V
NSC Code 714597 (see NCI DTP info)
PDQ Closed Trial Search ID 468469
PDQ Open Trial Search ID 468469 (check for NCI PDQ open clinical trial info)
UMLS CUI C0097147

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C4H5N3O
code C29115
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Imexon
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C29115

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