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Version: 17.06d (Release date: 2017-06-26)
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Gemfibrozil (Code C29071)

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Terms & Properties

Preferred Name: Gemfibrozil

Definition: A fibric acid derivative with hypolipidemic effects. Gemfibrozil interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. This enhances triglyceride-rich lipoprotein clearance and reduces the expression of apolipoprotein C-III (apoC-III). The reduction in hepatic production of apoC-III results in subsequent reduction of serum levels of very-low-density-lipoprotein cholesterol (VLDL-C). In addition, gemfibrozil-mediated PPARalpha stimulation of apoA-I and apoA-II expression results in an increase in high-density lipoprotein cholesterol (HDL-C).

Display Name: Gemfibrozil

Label: Gemfibrozil

NCI Thesaurus Code: C29071 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0017245  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
CAS Registry Number 25812-30-0 (see NLM ChemIDplus info)
FDA UNII Code Q8X02027X3
ChEBI ID CHEBI:5296 (see ChEBI info)
PDQ Closed Trial Search ID 715911
PDQ Open Trial Search ID 715911 (check for NCI PDQ open clinical trial info)
UMLS CUI C0017245

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C15H22O3
code C29071
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Gemfibrozil
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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