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Version: 17.06d (Release date: 2017-06-26)
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Fluvastatin Sodium (Code C29062)

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Terms & Properties

Preferred Name: Fluvastatin Sodium

Definition: The sodium salt of a synthetic lipid-lowering agent with potential antineoplastic activity. Fluvastatin competitively inhibits hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses through the suppression of MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. Through the inhibition of mevalonate synthesis, statins, like fluvastatin, have been shown to inhibit the production of dolichol, geranylpyrophosphate (GPP) and farnesylpyrophosphate (FPP) and the isoprenylation of the intracellular G-proteins Ras and Rho, which may result in antiangiogenic, apoptotic, and antimetastatic effects in susceptible tumor cell populations.

Display Name: Fluvastatin Sodium

Label: Fluvastatin Sodium

NCI Thesaurus Code: C29062 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0246203  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(3R,5S,6E)-(+/-)-7-(3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl)-3,5-dihydroxy-6-heptenoic Acid
Fluvastatin Sodium
FLUVASTATIN SODIUM
Lescol

External Source Codes: 
CAS Registry Number 93957-55-2 (see NLM ChemIDplus info)
FDA UNII Code PYF7O1FV7F
PDQ Closed Trial Search ID 487588
PDQ Open Trial Search ID 487588 (check for NCI PDQ open clinical trial info)
UMLS CUI C0246203

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C24H25FNO4.Na
code C29062
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Fluvastatin_Sodium
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C29062

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